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Nicox S.A. is the parent company of the Nicox Group and is based in France. The HQ is the corporate center of the company, with the Finance, Legal, Corporate Development and Communications & Investor relations Departments. Nicox S.A. has two international subsidiaries, one in North Carolina, in the United States, focused on development, and the other in Milan, Italy focused on research and nonclinical development.

The Nicox Research Institute in Milan is the Research and Nonclinical Development Center of the Company, with a team of scientists with significant expertise in the synthesis and biological testing of nitric oxide (NO)-donating molecules and in the early development of new molecular entities. The group works through collaborations with high-quality contract research organizations and universities throughout the world, and also manages the extensive Nicox patent portfolio.

Nicox Ophthalmics, Inc. in Durham, NC, is the therapeutic development subsidiary of the Company in which our Development Team has an in-depth experience in Chemistry, Manufacturing and Controls (CMC) and clinical development, with a strong focus in ophthalmology. They work with experienced and leading contract manufacturing and clinical research organizations to conduct our clinical studies.