Who we are
Nicox is an international ophthalmology company developing innovative solutions to help maintain vision and improve ocular health.

Nicox’ pipeline includes two ophthalmic products approved for commercialization in the U.S.: VYZULTATM (latanoprostene bunod ophthalmic solution), 0.024% and ZERVIATETM (cetirizine ophthalmic solution) 0.24%, formerly AC-170. VYZULTA, indicated for the reduction of intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension, is exclusively licensed worldwide to Bausch + Lomb and was launched by Bausch + Lomb in the U.S. in December 2017. ZERVIATE, indicated for the treatment of ocular itching associated to allergic conjunctivitis, has been exclusively licensed in the U.S. to Eyevance Pharmaceuticals and is planned to be launched there in the U.S. by Eyevance in late 2018. In addition to VYZULTA and ZERVIATE, Nicox has three programs in development: NCX 470 for IOP lowering in glaucoma, NCX 4251 for blepharitis, and NCX 4280 (exclusively licensed out worldwide to Ora, Inc.) for morning ocular congestion. NCX 470 for IOP lowering in glaucoma is based on Nicox proprietary nitric oxide (NO)-donating research platform. NCX 4251 for blepharitis and NCX 4280 for morning ocular congestion are product candidates based on repurposed, clinically and commercially validated molecules. Nicox’ pipeline also includes a next-generation of stand-alone NO-donors in the research stage and other exploratory novel NO-donating compounds targeting glaucoma.

The Company’s strategy is to become a fully integrated pharmaceutical company focused on the discovery, development and commercialization of novel ophthalmic therapeutics. This strategy includes the expansion of its ophthalmic product portfolio through internal discovery efforts based on its proprietary NO-donating research platform, the repurposing of established molecules and possible in-licensing activities or acquisitions of additional ophthalmic product candidates or products. Nicox was formed in 1996 and listed on Euronext Paris (Compartment B: Mid Caps; Ticker symbol: COX) in 1999. The Company is headquartered in Sophia Antipolis, France, has research facilities in Bresso, Italy, and a U.S. office in Fort Worth, Texas.

Our approach
The global ophthalmic market was valued at $18.6 billion in 2016 representing average annual growth over the past 5 years of approximately 5%.

Addressing a gap in the ophthalmic market

Certain areas in the ophthalmic market are expected to experience considerable growth due to a significant need for better treatments and diagnostic options. The ophthalmic market is currently dominated by large global pharmaceutical companies and much smaller national players. We see the opportunity for a targeted R&D organisation in ophthalmology. Our experienced team brings together a heritage of scientific, financial, business and corporate development expertise, strengthened by our own in-house research capabilities. Our growth strategy is based on the validated therapeutic effect of our proprietary NO-donating research platform, our other proprietary development assets and our partnered programs.  We intend to develop our portfolio through outstanding international collaborations and internal focus on our proprietary developments.

References:

IMS Health Analytics sales 2016

Nicox - Our approach
Partnerships
Partnerships have played an integral role in Nicox’s growth and the Company has demonstrated its expertise in managing successful international alliances with both leading pharmaceutical companies and biotechs. A significant number of the Company’s nitric oxide-donating compounds have been developed through collaborations with leading international pharmaceutical companies including Bausch + Lomb, Astra Zeneca, Merck, Pfizer.

Partnerships accelerate the advancement of Nicox’s research and development activities, allowing us to share and build our expertise and endorse the company’s nitric oxide-donating research platform. The Company expects partnerships to continue to have a significant place in its future development both through the partnering of assets already advanced by Nicox and through allowing us to access innovative science from external sources. We are always interested in hearing about potential collaborations and seek partners with complementary strengths who share our values; do not hesitate to contact us if you share our passion for visible science.

Our partners
Leadership team

Nicox is led by a team of experienced professionals whose combined expertise covers research, clinical development, regulatory interactions, finance, business and corporate development, alliance management and communication. This experience was acquired in leading pharmaceutical and biotech companies and the team includes Michele Garufi, one of  Nicox’s co-founders.

Board of directors

Nicox is proud to present its Board of Directors, whose members are highly experienced in the pharmaceutical and biotech industry.