Sophia Antipolis, France

Nicox SA (Euronext Paris: FR0013018124, COX), an international ophthalmology company, informs its shareholders that the ordinary general meeting was held on May 3, 2018 and all resolutions were approved. The extraordinary general meeting convened on first call could not be held as the quorum required by law was not reached.

The shareholders are thus convened on second call for an extraordinary general meeting on the same agenda on Thursday May 24, 2018 at 2:00 pm CET in the offices of BuroClub – Drakkar 2 – Bâtiment D – 2405 route des Dolines – 06560 Valbonne Sophia Antipolis – France.

The documents mentioned in articles R.225-73-1 of the French Code de commerce, including those to be presented at the general meeting, are available on the Company’s website www.nicox.com. These documents are also available to shareholders at the headquarters of the Company.

Shareholders may vote by proxy, by internet or by attending the shareholder meeting in person. A guide explaining how to vote, and notably how to vote by internet, is available on Nicox’s website. Shareholders may also contact the Company’s Investor Relations team at age2018@nicox.com for any question on the voting process. The proxy forms sent for the first call remain valid. Shareholders having requested to attend the May 3, 2018 extraordinary shareholder meeting may attend the May 24, 2018 meeting.

• NCX 667 demonstrates robust, dose-dependent lowering of intraocular pressure in various normotensive and hypertensive ocular models

Sophia Antipolis, France

Nicox SA (Euronext Paris: FR0013018124, COX), an international ophthalmology company, today announced a poster presentation highlighting scientific data for NCX 667, a novel nitric oxide (NO) donating compound, at the Association for Research in Vision and Ophthalmology (ARVO) 2018 Annual Meeting, one of the key scientific events in the ophthalmology calendar, being held on April 29 – May 3, 2018 in Honolulu, Hawaii, United States.

Synthesized and characterized by Nicox, NCX 667 is a lead molecule among the Company’s future generation of stand-alone NO-donors which are designed to optimize NO dosing and can be used alone or in combination with existing standard-of-care drugs, as either ophthalmic solutions or extended release formulations, to enable robust intraocular pressure (IOP)-lowering in patients with open-angle glaucoma or ocular hypertension.

The ARVO 2018 abstract by Francesco Impagnatiello, Ph.D., et al. describes results following single dose administration of various doses (0.1%, 0.3% and 1.0% solution) of NCX 667 in several ocular normotensive and ocular hypertensive animal models. These results demonstrate that NCX 667 lowers IOP in a dose-dependent manner. Furthermore, an in vitro bioengineered human trabecular meshwork/Schlemm’s canal (TM/SC) system was used to study the effects of NCX 667 on the conventional outflow facility. These data support the hypothesis that the IOP-lowering effects of NCX 667 are likely due to an increase in outflow facility via the TM/SC outflow pathway.

Michael Bergamini, Ph.D., Executive Vice President, Chief Scientific Officer of Nicox, commented: “The results presented at ARVO this year show a clear, dose-dependent, and meaningful lowering of IOP in both ocular normotensive and hypertensive models. These results, combined with the in vitro data, continue to build upon the growing body of scientific evidence supporting the development of NCX 667, a lead molecule among our future generation of stand-alone NO-donors. We are continuing to generate new compounds in this class and are testing multiple leads using topical and sustained release dosing.“

An estimated 3.5% of the worldwide population between 40 and 80 years of age are affected by the most common forms of glaucoma¹.

The ARVO 2018 abstracts have been published in the meeting website located at https://www.arvo.org/annual-meeting/ and details for the poster presentation are as follows:

Title: NCX 667, a novel nitric oxide (NO) donor lowers intraocular pressure (IOP) via stimulation of trabecular meshwork/Schlemm’s canal outflow facility

Date and time: Wednesday, May 2, 2018 from 11:15 am to 1:00 pm HAST

Presenter: Francesco Impagnatiello, Ph.D. , Nicox Research Institute

Session n° 448, Title: Glaucoma – Trabecular Meshwork

Abstract n°: 4707 / Poster n°: B0131

Location: Hawaii Convention Center, Exhibit Hall

About NCX 667

NCX 667 is a lead molecule among the Company’s future generation of stand-alone NO-donors. Preclinical results obtained in rabbits and dogs with normal IOP and in rabbit and non-human primate models of ocular hypertension demonstrate rapid and sustained IOP lowering compared to vehicle following repeated dosing with no signs of tachyphylaxis or ocular discomfort.

Note:

1. Tham YC, Li X, Wong TY, Quigley HA, Aung T, Cheng CY. Global prevalence of glaucoma and projections of glaucoma burden through 2040: a systematic review and meta-analysis. Ophthalmology. 2014;121(11):2081–2090.